Dimers of β2-Glycoprotein I Mimic thein Vitro Effects of β2-Glycoprotein I-Anti-β2-glycoprotein I Antibody Complexes

Optimization of Unnicked β2-Glycoprotein I and High Avidity Anti-β2-Glycoprotein I Antibodies Isolation

Patient biological material for isolation of β2-glycoprotein I (β2GPI) and high avidity IgG anti-β2-glycoprotein I antibodies (HAv anti-β2GPI) dictates its full utilization. The aim of our study was to evaluate/improve procedures for isolation of unnicked β2GPI and HAv aβ2GPI to gain unmodified proteins in higher yields/purity. Isolation of β2GPI from plasma was a stepwise procedure combining n...

Structural Changes in β2-Glycoprotein I and the Antiphospholipid Syndrome

Anti-β2 glycoprotein-I antibody increases the risk of pregnancy-induced hypertension: a case-control study

The aim of this study was to evaluate whether IgG, IgM anti-β2 glycoprotein-I antibody (anti-β 2GPI) was associated with the development of pregnancy-induced hypertension (PIH) or pre-eclampsia in the Japanese population. This study was performed as a case-control study in cohort. The peripheral blood was obtained at 8-14 weeks of gestation from a consecutive series of 1,155 women. The case gro...

Association of anticardiolipin, antiphosphatidylserine, anti-β2 glycoprotein I, and antiphosphatidylcholine autoantibodies with canine immune thrombocytopenia

BACKGROUND In humans, the presence of antiphospholipid antibodies (aPL) is frequently found in immune thrombocytopenia. The present study investigated whether aPL and any aPL subtypes are associated with canine thrombocytopenia, in particular, immune-mediated thrombocytopenia (immune thrombocytopenia) that usually manifests with severe thrombocytopenia. RESULTS Sera were collected from 64 out...

Inhibition of Apc Anticoagulant Activity on Oxidized Phospholipid by Anti-β2-glycoprotein I Monoclonal Antibodies

This research was supported by a Specialized Center on Thrombosis grant awarded by the National Heart, Lung and Blood Institute of the National Institutes of Health (grant no. P50 HL54502; NLE). CTE is an investigator of the Howard Hughes Medical Institute and holds the Lloyd Noble Chair in Cardiovascular Research at the Oklahoma Medical Research Foundation. *O. Safa current address: Biomerieux...